5 0.1 1 10 100 0.01 Particle size (μm) Human sneeze Spores Hydrocarbon aerosol Bacteria Viruses Suspended inorganic dust Coarse filters Medium/fine filters HEPA/ULPA filters Typical Size Range of Airborne Contaminants Filter Type Figure 1 Balancing High Level Protection With Total Cost of Ownership No clean air is possible without a carefully selected and reliably functioning air filtration system. The performance of installed air filters, whether terminal filters or prefilters, directly determines how effectively harmful contaminants are prevented from entering the airstream in process environments. However, if the Facility Managers selecting air filters do not also consider the lifetime operating costs of a given product, facilities could be exposed to unnecessary risks and expenses. Air in critical areas should always be supplied at the terminal stage by HEPA filtered unidirectional airflow, preceded by sequential prefiltration steps. Leak-free and high filtration efficiency performance of the HEPA filter is vital for ensuring that air purity is optimized, the pressure differentials between rooms are met, and healthy working conditions are achieved. TCO Diagnostic® A thorough air filter audit of your HVAC Systems is the first step in order to provide you with professional guidance and analysis for cost savings and risk reduction. By conducting this audit, AAF Flanders will be able to understand your current state and then utilize TCO Diagnostic,® an advanced analytical software tool, to identify how you can perform even better. The purpose of TCO Diagnostic is to assist you in selecting the best filters for your air handling systems and to understand their sensitivity to your operating conditions, in order for your system to operate in the most optimal and effective manner. TCO Diagnostic provides the insight to identify improvement opportunities, find the optimized options, and tailor to your specific needs for a comprehensive purchase perspective— improving air quality, energy savings, and operational flexibility while reducing Total Cost of Ownership. Typical Airborne Contaminants Airborne contaminants differ in size and impact in a pharmaceutical manufacturing process. Figure 1 shows a typical size range of airborne particles and microorganisms. Each particle size range requires a specific air filtration technique to obtain the required air quality levels.
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